Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …

Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles
and show promise as therapeutic targets in human cancers, including acute myeloid …

This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia
(AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly …

BCL-2 inhibition has been shown to be effective in acute myeloid leukemia (AML) in
combination with hypomethylating agents or low-dose cytarabine. However, resistance and …

Overcoming anticancer drug resistance is a major challenge in cancer therapy, requiring
innovative strategies that consider the extensive tumor heterogeneity and adaptability. We …

Mitochondrial metabolites regulate leukaemic and normal stem cells by affecting epigenetic
marks. How mitochondrial enzymes localize to the nucleus to control stem cell function is …

Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are usually associated
with poor outcomes, especially in high‐risk AML/MDS. Allogeneic hematopoietic stem cell …

Metabolic alterations in cancer represent convergent effects of oncogenic mutations. We
hypothesized that a metabolism-restricted genetic screen, comparing normal primary mouse …

Acute myeloid leukemia is characterized by the accumulation of clonal myeloid blast cells
unable to differentiate into mature leukocytes. Chemotherapy induces remission in the …