Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …

Distinct from the traditional diagnostic/prognostic biomarker (adopted as the indicator of
disease state/process), the therapeutic biomarker (ThMAR) has emerged to be very crucial …

The efficacy and safety of drugs are widely known to be determined by their interactions with
multiple molecules of pharmacological importance, and it is therefore essential to …

Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

De novo drug development is an extremely complex, time-consuming and costly task.
Urgent needs for therapies of various diseases have greatly accelerated searches for more …

Bioinformatic annotation of protein function is essential but extremely sophisticated, which
asks for extensive efforts to develop effective prediction method. However, the existing …

The discovery of proper molecular signature from OMIC data is indispensable for
determining biological state, physiological condition, disease etiology, and therapeutic …

The phenotypic and regulatory variability of drug transporter (DT) are vital for the
understanding of drug responses, drug-drug interactions, multidrug resistances, and so on …

Large-scale metabolomics is a powerful technique that has attracted widespread attention in
biomedical studies focused on identifying biomarkers and interpreting the mechanisms of …

Human dopamine transporter (hDAT) regulates the reuptake of extracellular dopamine (DA)
and is an essential therapeutic target for central nervous system (CNS) diseases. The …