Abstract Significance: Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among
the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of …

Iron, an indispensable element for life, is involved in all kinds of important physiological
activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress …

Introduction Given the severity of the condition and the increasing number of patients,
developing effective therapies for Alzheimer's disease has become a significant necessity …

A number of studies performed on biological systems have shown that redox-active metals
such as iron and copper as well as other transition metals can undergo redox cycling …

Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia,
increased susceptibility to infections and vaso‐occlusion leading to a reduced quality of life …

Purpose Heart failure (HF) remains a major cause of morbidity and mortality worldwide.
Although various therapies developed over the last two decades have shown improved long …

Deferasirox is an orally effective iron (Fe) chelator currently used for the treatment of iron-
overload disease and has been implemented as an alternative to the gold standard chelator …

Introduction: Oxidative stress (caused by excess iron) can result in tissue damage, organ
failure and finally death, unless treated by iron chelators. The causative factor in the etiology …

Alzheimer's disease (AD) is the age linked neurodegenerative disorder with no disease
modifying therapy currently available. The available therapy only offers short term …

Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective
anticancer drugs, but their usefulness is hampered by the risk of irreversible cardiotoxicity …