Mammalian cells possess a multifaceted antioxidant enzyme system, which includes
superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione …

Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a
paramount process in regulating systemic energy metabolism. Reactive oxygen and …

Background Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed,
epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue …

Background The most important health benefit of selenium (Se) is in the prevention and
control of cancer. Glutathione peroxidases (GPXs) and thioredoxin reductases (TXNRDs) …

Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently,
lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR …

Type 2 diabetes (T2D) is considered one of the largest global public-health concerns,
affecting approximately more than 400 million individuals worldwide. The pathogenesis of …

Background/Aims: Altered expression and circulating levels of glutathione peroxidase 3
(GPX3) have been observed in obesity and type 2 diabetes (T2D) across species. Here, we …

Diabetic type 2 patients compared to nondiabetic patients exhibit an increased risk of
developing diabetic kidney disease (DKD), the leading cause of end‐stage renal disease …

Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in
organisms; these enzymes promote hydrogen peroxide metabolism and protect cell …

Aim: To evaluate if the TG/HDL-C index can be considered as a reference criterion of MetS
and low insulin sensitivity in apparently healthy subjects. Methods: The subjects were …