Targeting PD-1/PD-L1 in tumor immunotherapy: Mechanisms and interactions with host growth regulatory pathways

S Shen, Y Hong, J Huang, X Qu, SR Sooranna… - Cytokine & Growth …, 2024 - Elsevier
Tumor immunotherapy has garnered considerable attention, emerging as a new standard of
care in cancer treatment. The conventional targets, such as VEGF and EGFR, have been …

Triple Combination of Immune Checkpoint Inhibitors and BRAF/MEK Inhibitors in BRAFV600 Melanoma: Current Status and Future Perspectives

M Welti, F Dimitriou, R Gutzmer, R Dummer - Cancers, 2022 - mdpi.com
Simple Summary With the development of immunotherapies and targeted therapies in the
last years, there has been great progress in the outcome of patients with metastatic …

Sequencing Targeted and Immune Therapy in BRAF-Mutant Melanoma: Lessons Learned

C Trojaniello, F Sparano, E Cioli, PA Ascierto - Current Oncology Reports, 2023 - Springer
Abstract Purpose of Review The treatment strategy for BRAF-mutated melanoma remains
unsatisfactory, although the advent of immune checkpoint inhibition has improved the …

Immunotherapy options for acral melanoma, a fast-growing but neglected malignancy

JA Gajón, A Juarez-Flores, SGDL Rodríguez… - Archives of Medical …, 2022 - Elsevier
Melanoma is the deadliest form of skin cancer. It is classified as cutaneous and non-
cutaneous, with the former characterized by developing in sun-exposed areas of the skin …

Brain metastases and lung cancer: molecular biology, natural history, prediction of response and efficacy of immunotherapy

M Sereno, I Hernandez de Córdoba… - Frontiers in …, 2024 - frontiersin.org
Brain metastases stemming from lung cancer represent a common and challenging
complication that significantly impacts patients' overall health. The migration of these …

The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in …

R Dummer, M Welti, E Ramelyte - Journal of Translational Medicine, 2023 - Springer
Novel therapies have achieved unprecedented benefit in survival of advanced melanoma
patients. While immunotherapy (ICI) can be administered independent of mutational status …

A mathematical model for the treatment of melanoma with the BRAF/MEK inhibitor and Anti-PD-1

OP Nave, M Sigron - Applied Sciences, 2022 - mdpi.com
Skin cancer treatment is a combination of BRAF and MEK kinase inhibitors administered as
tablets, along with immunotherapy treatment (treatment into the vein) with a group of drugs …

Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma

G Li, T Wu, H Li, C Wei, Y Sun, P Gao, X Huang… - Journal of Translational …, 2024 - Springer
Background Skin cutaneous melanoma (SKCM) poses a significant public health challenge
due to its aggressive nature and limited treatment options. To address this, the study …

[HTML][HTML] Delayed and Concurrent Stereotactic Radiosurgery in Immunotherapy-Naïve Melanoma Brain Metastases

CE Hadley, JK Matsui, DM Blakaj, S Beyer, JC Grecula… - Cancers, 2024 - mdpi.com
Melanoma remains a formidable challenge in oncology, causing the majority of skin cancer
deaths in the United States, with brain metastases contributing substantially to this mortality …

[HTML][HTML] Effective control of postoperative recurrence of pregnancy-related gastric cancer using anti-PD-1 as a monotherapy: a case report

X Liu, X Li, C Zhu, L Ji - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
Pregnancy-related gastric cancer is characterized by a refractory nature and poor prognosis;
few gastric cancer cases during pregnancy achieved acceptable outcomes by using anti-PD …