Functioning and processing of membrane proteins critically depend on the way their
transmembrane segments are embedded in the membrane. Sphingolipids are structural …

Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-
coated vesicles and then progress through the Golgi complex before delivery to their final …

Autophagy is an important cellular degradation pathway present in all eukaryotic cells. Via
this pathway, portions of the cytoplasm and/or organelles are sequestered in double …

The secretory pathway in mammalian cells has evolved to facilitate the transfer of cargo
molecules to internal and cell surface membranes. Use of automated microscopy-based …

Elevated plasma cholesterol levels are considered responsible for excess cardiovascular
morbidity and mortality. Cholesterol in plasma is tightly controlled by cholesterol within cells …

Nasopharyngeal carcinoma (NPC), a highly metastatic and invasive malignant tumor
originating from the nasopharynx, is widely prevalent in Southeast Asia, the Middle East and …

Previous biochemical work has revealed two parallel routes of exit from the endoplasmic
reticulum (ER) in the yeast Saccharomyces cerevisiae, one seemingly specific for glycosyl …

Rabs and Arfs/Arls are Ras-related small GTPases of particular relevance to membrane
trafficking. It is thought that these proteins regulate specific pathways through interactions …

The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins.
To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the …

Maintaining the optimal performance of cell processes and organelles is the task of auto-
regulatory systems. Here we describe an auto-regulatory device that helps to maintain …