Mechanisms of diabetic complications
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …
required, but also for its major complications, affecting both small and large blood vessels …
Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies
Introduction: Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in
diabetes and is the most common cause of proteinuric and non-proteinuric forms of end …
diabetes and is the most common cause of proteinuric and non-proteinuric forms of end …
AGE-RAGE axis blockade in diabetic nephropathy: current status and future directions
Diabetic nephropathy is one of the most frequent micro-vascular complications both in type 1
and type 2 diabetic patients and is the leading cause of end-stage renal disease worldwide …
and type 2 diabetic patients and is the leading cause of end-stage renal disease worldwide …
Dietary factors and low-grade inflammation in relation to overweight and obesity
Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases
many inflammatory mediators. The source of these mediators within adipose tissue is not …
many inflammatory mediators. The source of these mediators within adipose tissue is not …
Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications
R Ramasamy, SF Yan… - Annals of the New York …, 2011 - Wiley Online Library
The receptor for advanced glycation endproducts (RAGE) was first described as a signal
transduction receptor for advanced glycation endproducts (AGEs), the products of …
transduction receptor for advanced glycation endproducts (AGEs), the products of …
Oxidative stress as a major culprit in kidney disease in diabetes
It is postulated that localized tissue oxidative stress is a key component in the development
of diabetic nephropathy. There remains controversy, however, as to whether this is an early …
of diabetic nephropathy. There remains controversy, however, as to whether this is an early …
The role of advanced glycation end products in progression and complications of diabetes
Context: Diabetic complications appear to be multifactorial in origin, but in particular, the
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …
Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets
R Pichler, M Afkarian, BP Dieter… - American Journal of …, 2017 - journals.physiology.org
Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …
Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?
Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost
25%. This increase may be partially attributable to lifestyle changes and increased global …
25%. This increase may be partially attributable to lifestyle changes and increased global …
Oxidative stress in ESRD patients on dialysis and the risk of cardiovascular diseases
J Rysz, B Franczyk, J Ławiński, A Gluba-Brzózka - Antioxidants, 2020 - mdpi.com
Chronic kidney disease is highly prevalent worldwide. The decline of renal function is
associated with inadequate removal of a variety of uremic toxins that exert detrimental …
associated with inadequate removal of a variety of uremic toxins that exert detrimental …