Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the
human lifespan that can increase the risk of low back pain. More clarification of the …

Exercise is a nonpharmacological intervention that improves health during aging and a
valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently …

Quiescence regulation is essential for adult stem cell maintenance and sustained
regeneration. Our studies uncovered that physiological changes in mitochondrial shape …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Physical training is a potent therapeutic approach for improving mitochondrial health
through peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) …

The clearance of damaged or unwanted mitochondria by autophagy (also known as
mitophagy) is a mitochondrial quality control mechanism postulated to play an essential role …

The dynamicity of the mitochondrial network is crucial for meeting the ever‐changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …

From quiescence to activation and myogenic differentiation, muscle stem cells (MuSCs)
experience drastic alterations in their signaling activity and metabolism. Through balanced …

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging.
Here, we asked whether the mitochondrial antiviral signaling protein (MAVS), which is …