Conspectus Drug-induced acute liver injury (DIALI) is increasingly recognized as a
significant cause of acute liver injury (ALI), which is characterized by a rapid loss of …

The level of serum alanine aminotransferase (ALT) activity reflects damage to hepatocytes
and is considered to be a highly sensitive and fairly specific preclinical and clinical …

In the pharmaceutical industry, improving the early detection of drug-induced hepatotoxicity
is essential as it is one of the most important reasons for attrition of candidate drugs during …

No consensus exists on how to address possible toxicity of nanomaterials as they interfere
with most in vitro screening tests based on colorimetric and fluorimetric probes such as the …

Drug candidate and toxicity screening processes currently rely on results from early-stage in
vitro cell-based assays expected to faithfully represent essential aspects of in vivo …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Liver plays a central role in the metabolism and excretion of xenobiotics which makes it
highly susceptible to their adverse and toxic effects. Liver injury caused by various toxic …

Although they have several important limitations primary human hepatocytes still represent
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …

To develop and validate a practical, in vitro, cell-based model to assess human
hepatotoxicity potential of drugs, we used the new technology of high content screening …

Drug-induced liver injury (DILI) is the most common adverse event causing drug
nonapprovals and drug withdrawals. Using drugs as test agents and measuring a panel of …