[HTML][HTML] Mechanistic insights and perspectives involved in neuroprotective action of quercetin

AK Grewal, TG Singh, D Sharma, V Sharma… - Biomedicine & …, 2021 - Elsevier
Neurodegenerative diseases (NDDs) are the primary cause of disabilities in the elderly
people. Growing evidence indicates that oxidative stress, mitochondrial dysfunction …

Apoptotic pathways and Alzheimer's disease: probing therapeutic potential

VK Sharma, TG Singh, S Singh, N Garg… - Neurochemical …, 2021 - Springer
Apoptosis is an intrinsic biochemical, cellular process that regulates cell death and is crucial
for cell survival, cellular homeostasis, and maintaining the optimum functional status …

[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, D Gupta, P Edison - Ageing Research Reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Metformin role in Parkinson's disease: a double-sword effect

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb… - Molecular and Cellular …, 2024 - Springer
Parkinson's disease (PD) is a common neurodegenerative disease developed due to the
degeneration of dopaminergic neurons in the substantia nigra. There is no single effective …

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective

M Alrouji, HM Al‐kuraishy, AI Al‐Gareeb… - Journal of Cellular …, 2023 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease (AD). Genetic predisposition and immune dysfunction are involved in …

Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives

F Ferrari, A Moretti, RF Villa - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Calpain inhibitors as potential therapeutic modulators in neurodegenerative diseases

H Khan, N Garg, TG Singh, A Kaur, K Thapa - Neurochemical Research, 2022 - Springer
It is considered a significant challenge to understand the neuronal cell death mechanisms
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …

[HTML][HTML] Animal models of diabetic microvascular complications: Relevance to clinical features

R Singh, SA Farooq, A Mannan, TG Singh… - Biomedicine & …, 2022 - Elsevier
Diabetes has become more common in recent years worldwide, and this growth is projected
to continue in the future. The primary concern with diabetes is developing various …

[HTML][HTML] NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders

Y Zilberter, DR Tabuena, M Zilberter - Progress in Neurobiology, 2023 - Elsevier
Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are
difficult to treat due to the lack of understanding of primary initiating factors. Meanwhile …