Among 20 leading global risk factors for years of life lost in 2040, reference forecasts point to
three metabolic risks—high blood pressure, high BMI, and high fasting plasma glucose—as …

Background Heterogeneity in type 2 diabetes presentation and progression suggests that
precision medicine interventions could improve clinical outcomes. We undertook a …

Abstract Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for
which the underlying biological mechanisms are not fully understood. In this study, we …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes. To characterise the genetic contribution to these processes …

Obesity is a complex and heterogeneous condition that leads to various metabolic
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date …

Genome-wide association studies (GWAS) of type 2 diabetes have identified few loci
connected to muscle biology. A GWAS of post-glucose-challenge measures of insulin has …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …

Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney
function, affecting approximately 9.1% of the world's population. Here, we use a soft …

Abstract Background Type 2 diabetes (T2D) is a heterogeneous and polygenic disease.
Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants …

Despite the importance of gene-environment interactions (GxEs) in improving and
operationalizing genetic discovery, interpretation of any GxEs that are discovered can be …