The peripheral nervous system (PNS) has remarkable regenerative abilities after injury.
Successful PNS regeneration relies on both injured axons and non-neuronal cells, including …

In this review, we first provide a brief historical perspective, discussing how peripheral nerve
injury (PNI) may have caused World War I. We then consider the initiation, progression, and …

Peripheral nerves regenerate following injury due to the effective activation of the intrinsic
growth capacity of the neurons and the formation of a permissive pathway for outgrowth due …

Multidomain peptide (MDP) hydrogels are a class of self-assembling materials that have
been shown to elicit beneficial responses for soft tissue regeneration. However, their …

As lysosomal hydrolysis has long been suggested to be responsible for myelin clearance
after peripheral nerve injury, in this study, we investigated the possible role of …

Impairment of peripheral neurons by anti-cancer agents, including taxanes and platinum
derivatives, has been considered to be a major cause of chemotherapy-induced peripheral …

Hydrogen sulfide (H2S) is an emerging neuromodulator that is considered to be a
gasotransmitter similar to nitrogen oxide (NO) and carbon monoxide (CO). H2S exerts …

The mechanisms that trigger Wallerian degeneration (WD) of peripheral nerves after injury
are not well understood. During the early period of WD, fragmentation of myelin into ovoid …

Axonal degeneration is a pivotal feature of many neurodegenerative conditions and
substantially accounts for neurological morbidity. A widely used experimental model to study …

Oxidative stress contributes to the progression of neurodegenerative diseases of the central
and peripheral nervous systems, including Alzheimer's disease, Parkinson's disease, stroke …