Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen
availability. When oxygen becomes limiting, the central transcription factors of the pathway …

The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …

Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master
regulator of oxygen homeostasis in almost all nucleated mammalian cells. The fundamental …

Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in
tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of …

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ
significantly among individuals and are difficult to model with genetically engineered lines of …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …

Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …

A hypoxic microenvironment contributes to tumor progression, with hypoxia-inducible factor-
1α (HIF-1α) being a critical regulator. We have reported that 14-3-3σ is negatively …

In addition to being structurally related, the protein modifiers ubiquitin and SUMO (small
ubiquitin-related modifier), share a multitude of functional interrelations. These include the …