Crosstalk between m6A modification and alternative splicing during cancer progression

ZM Zhu, FC Huo, J Zhang, HJ Shan… - Clinical and …, 2023 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A), the most prevalent internal mRNA
modification in eukaryotes, is added by m6A methyltransferases, removed by m6A …

mRNA accessibility within mRNPs as a determinant of gene expression

PC He, C He - Trends in Biochemical Sciences, 2024 - cell.com
Gene expression is a complex process requiring many control mechanisms to achieve a
desired phenotype. DNA accessibility within chromatin is well established as an important …

Determinant of m6A regional preference by transcriptional dynamics

Y Wang, S Wang, Z Meng, XM Liu… - Nucleic Acids …, 2024 - academic.oup.com
Abstract N6-Methyladenosine (m6A) is the most abundant chemical modification occurring
on eukaryotic mRNAs, and has been reported to be involved in almost all stages of mRNA …

m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells

Q Zhou, X Liu, H Lu, N Li, J Meng, J Huang… - Journal of …, 2024 - Springer
Retinal neovascularization (RNV) disease is one of the leading causes of blindness, yet the
molecular underpinnings of this condition are not well understood. To delve into the critical …

[PDF][PDF] Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA

CJ Aufgebauer, KM Bland, SM Horner - Cell Chem Biol, 2024 - cell.com
Viral infection and the antiviral innate immune response are regulated by the RNA
modification m6A. m6A directs nearly all aspects of RNA metabolism by recruiting RNA …

Challenges to mapping and defining m6A function in viral RNA

SM Horner, MG Thompson - RNA, 2024 - rnajournal.cshlp.org
Viral RNA molecules contain multiple layers of regulatory information. This includes features
beyond the primary sequence, such as RNA structures and RNA modifications, including N6 …

Targeting m6A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels

X Zheng, S Deng, Y Li, Z Luo, Z Gan, Z Zheng, R Xu… - Biomaterials, 2025 - Elsevier
Chronic diabetic wounds are a prevalent and severe complication of diabetes, contributing
to higher rates of limb amputations and mortality. N6-methyladenosine (m 6 A) is a common …

Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy

S Imani, X Li, K Chen, M Maghsoudloo… - Frontiers in Cellular …, 2025 - frontiersin.org
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer
immunotherapy, requiring optimal design to elicit a robust and targeted immune response …

Decoding the specificity of m6A RNA methylation and its implication in cancer therapy

Y Cun, W Guo, B Ma, Y Okuno, J Wang - Molecular Therapy, 2024 - cell.com
Abstract N6-methyladenosine (m 6 A) is the most abundant endogenous modification in
eukaryotic RNAs. It plays important roles in various biological processes and diseases …

N-6-Methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5′ splice site motifs

ES Lee, HW Smith, YE Wang, SSJ Ihn… - Life Science …, 2025 - life-science-alliance.org
In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′ SS) motifs are
nuclear retained and targeted for decay by ZFC3H1, a component of the Poly (A) Exosome …