Quantitative or qualitative defects of von Willebrand factor (VWF) are responsible for the
most common inherited bleeding disorder, von Willebrand disease (VWD). Type 2N VWD is …

Von Willebrand disease (VWD) is a common bleeding disorder of platelet adhesion with six
currently recognized subtypes. Laboratory diagnosis consists of an initial test panel …

Abstract von Willebrand disease (VWD) type 2 is caused by qualitative abnormalities of von
Willebrand factor (VWF). This study aimed to determine the genotypic and phenotypic …

Introduction In the network of US comprehensive haemophilia treatment centres (HTCs), von
Willebrand disease (VWD) is the most common bleeding disorder other than haemophilia …

Background Several assays are now available to evaluate platelet-dependent von
Willebrand factor (VWF) activity. Objective To report the results obtained using 4 different …

Background An appropriate clinical diagnosis of von Willebrand disease (VWD) can be
challenging because of a variable bleeding pattern and laboratory phenotype. Genotyping is …

Abstract Introduction Diagnosing von Willebrand Disease (VWD) in adolescent females is
challenging as menstruation and physiologic stress elevate von Willebrand factor (VWF) …

Essentials• VWF and FVIII increase with age in patients affected by VWD.• VWF and FVIII
increase in type 1 and in low levels of VWF patients.• VWF and FVIII do not increase in type …

Abstract von Willebrand disease (VWD) is the most frequent inherited bleeding disorder with
an estimated symptomatic prevalence of 1 per 1,000 in the general population. VWD is …

Diagnosis of rare bleeding disorders is challenging and there are several differential
diagnostics issues. Next-generation sequencing (NGS) is a useful tool to overcome these …