High-dose intravenously administered vitamin C (IVC) is widely used in cancer patients by
complementary and alternative medicine practitioners. The most frequent indications for IVC …

Highlights•Naringin induced a marked decrease of renal injury markers in MTX-treated
rats.•Naringin protected against redox imbalance of renal tissue in MTX-treated …

Dioscin, one natural product, has various pharmacological actions. However, its effects on
methotrexate (MTX)-induced hepatorenal damages still remain unknown. In the present …

Moringa Oleifera (MO) is a herbal plant native to South Asia known for its anti-oxidative and
anti-inflammatory properties. This study explored the protective effects of MO leaf extract …

The main focus of our study is to assess the anti-cancer activity of cimetidine and vitamin C
via combating the tumor supportive role of mast cell mediators (histamine, VEGF, and TNF …

Hepatic injury is a major side effect associated with methotrexate (MTX) therapy resulting
from inflammatory reactions and oxidative stress induction. Therefore, liver fibrosis incidence …

Nephrotoxicity is the major dose-limiting adverse effect of methotrexate (MTX).
Umbelliferone (UMB) is a known coumarin derivative. The current study aimed to investigate …

Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic
inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects …

Drug‐induced liver injury (DILI) is the main cause of liver damage mediated by the excretion
of toxic active drug metabolites. Omega‐3 fatty acids and vitamin C have potent antioxidant …

Waterpipe tobacco smoking (WTS) was previously shown to be associated with memory
deficits, which were related to oxidative stress. Vitamin C (VitC) has established antioxidant …