Ions surround nucleic acids in what is referred to as an ion atmosphere. As a result, the
folding and dynamics of RNA and DNA and their complexes with proteins and with each …

RNA folding into stable tertiary structures is remarkably sensitive to the concentrations and
types of cations present; an understanding of the physical basis of ion-RNA interactions is …

The sequencing of the human genome and the elucidation of many molecular pathways that
are important in disease have provided unprecedented opportunities for the development of …

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired
stems and a core of highly conserved, non-complementary nucleotides essential for …

Synthetic oligonucleotide analogs have greatly aided our understanding of several
biochemical processes. Efficient solid-phase and enzyme-assisted synthetic methods and …

We previously reported the in vitro selection of a general-purpose RNA-cleaving DNA
enzyme that exhibits a catalytic efficiency (k cat/KM) exceeding that of any other known …

Background: Previously we demonstrated that DNA can act as an enzyme in the Pb 2t-
dependent cleavage of an RNA phosphoester. This is a facile reaction, with an uncatalyzed …

A group of highly efficient Zn (II)-dependent RNA-cleaving deoxyribozymes has been
obtained through in vitro selection. They share a common motif with the '8 …

▪ Abstract The past few years have seen exciting advances in understanding the structure
and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed …

Minimal hammerhead ribozymes have been characterized extensively by static and time-
resolved crystallography as well as numerous biochemical analyses, leading to mutually …