Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
Membrane-initiated estrogen, androgen, and progesterone receptor signaling in health and disease
Rapid effects of steroid hormones were discovered in the early 1950s, but the subject was
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
dominated in the 1970s by discoveries of estradiol and progesterone stimulating protein …
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …
Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer
The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …
Non-genomic actions of the androgen receptor in prostate cancer
Androgen receptor (AR) is a validated drug target for prostate cancer based on its role in
proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent …
proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent …
Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer
G Galletti, BI Leach, L Lam, ST Tagawa - Cancer treatment reviews, 2017 - Elsevier
Patients with metastatic castration-resistant prostate cancer (mCPRC) now have an
unprecedented number of approved treatment options, including chemotherapies …
unprecedented number of approved treatment options, including chemotherapies …
The androgen receptor in prostate cancer: Effect of structure, ligands and spliced variants on therapy
EA Messner, TM Steele, MM Tsamouri, N Hejazi… - Biomedicines, 2020 - mdpi.com
The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …
consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …
Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance
P Bond - Journal of the International Society of Sports Nutrition, 2016 - Springer
The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) plays a pivotal role
in the regulation of skeletal muscle protein synthesis. Activation of the complex leads to …
in the regulation of skeletal muscle protein synthesis. Activation of the complex leads to …
Molecular pathogenesis and progression of prostate cancer
R Schrecengost, KE Knudsen - Seminars in oncology, 2013 - Elsevier
Prostate cancer (PCa) is the most commonly diagnosed noncutaneous malignancy and
second leading cause of cancer-related deaths in US males. Clinically, locally confined …
second leading cause of cancer-related deaths in US males. Clinically, locally confined …
Androgen receptor phosphorylation: biological context and functional consequences
Y Koryakina, HQ Ta, D Gioeli - Endocrine-related cancer, 2014 - erc.bioscientifica.com
The androgen receptor (AR) is a ligand-regulated transcription factor that belongs to the
family of nuclear receptors. In addition to regulation by steroid, the AR is also regulated by …
family of nuclear receptors. In addition to regulation by steroid, the AR is also regulated by …