Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17
million deaths per year, which outpaces global cancer mortality rates. Despite these …

There is a growing scientific consensus on climate change and its impact on catchment
scale hydrologic and water quality processes. Therefore, it is not only important to …

Arterial hypertension can lead to structural changes within the heart including left ventricular
hypertrophy (LVH) and eventually heart failure with preserved ejection fraction (HFpEF). The …

The extracellular matrix (ECM) actively participates in diverse aspects of cardiovascular
development and physiology as well as during disease development and progression. ECM …

It is widely accepted that molecular reductionist views of highly complex human physiologic
activity, eg, the aging process, as well as therapeutic drug efficacy are largely …

Myocardial ischemic injury and its resolution are the key determinants of morbidity or
mortality in heart failure. The cause and duration of ischemia in patients vary. Numerous …

Cardiac remodeling (CR) is a complex dynamic process common to many heart diseases.
CR is characterized as a temporal progression of global adaptive and maladaptive …

Identifying the genes and proteins associated with a biological process or disease is a
central goal of the biomedical research enterprise. However, relatively few systematic …

Machine learning uses historical data to make predictions about new data. It has been
frequently applied in healthcare to optimise diagnostic classification through discovery of …