Quercetin derivatives: Drug design, development, and biological activities, a review

SR Alizadeh, MA Ebrahimzadeh - European journal of medicinal chemistry, 2022 - Elsevier
More studies are needed to develop new drugs for problems associated with drug
resistance and unfavorable side effects. The natural flavonoid of quercetin revealed a wide …

[HTML][HTML] On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

EI Vrettos, G Mező, AG Tzakos - Beilstein journal of organic …, 2018 - beilstein-journals.org
Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …

Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives

SR Alizadeh, N Savadkouhi… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Scientists are especially interested in polyphenols, particularly flavonoids.
Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as …

Quercetin: a potential polydynamic drug

N Georgiou, MG Kakava, EA Routsi, E Petsas… - Molecules, 2023 - mdpi.com
The study of natural products as potential drug leads has gained tremendous research
interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and …

Probing the interaction of a quercetin bioconjugate with Bcl‐2 in living human cancer cells with in‐cell NMR spectroscopy

A Primikyri, N Sayyad, G Quilici, EI Vrettos, K Lim… - FEBS …, 2018 - Wiley Online Library
In‐cell NMR spectroscopy has emerged as a powerful technique for monitoring
biomolecular interactions at an atomic level inside intact cells. However, current …

[HTML][HTML] Ligand-observed in-tube NMR in natural products research: A review on enzymatic biotransformations, protein–ligand interactions, and in-cell NMR …

IP Gerothanassis - Arabian Journal of Chemistry, 2023 - Elsevier
Natural product-observed NMR methods have considerably expanded the potentialities for
in-tube NMR monitoring of complex enzymatic biotransformations and investigation of …

Recent insights into therapeutic potential of plant-derived flavonoids against cancer

R Mohi-Ud-Din, RH Mir, S Sabreen… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Flavonoids, a class of polyphenolic secondary metabolites, are present in fruits, vegetables,
beverages such as wine and tea abundantly. Flavonoids exhibit a diverse array of …

Research Progress on Quercetin's Biological Activity and Structural Modification Based on Its Antitumor Effects

M Guo, J Zeng, Z Sun, X Wu, Z Hu - ChemistrySelect, 2023 - Wiley Online Library
Quercetin is a naturally existing flavonoid with numerous physiological effects, including
antitumor activity. It functions as an antitumor agent by inducing apoptosis and inhibiting …

Design principles governing the development of theranostic anticancer agents and their nanoformulations with photoacoustic properties

SG Kyrkou, EI Vrettos, D Gorpas, T Crook, N Syed… - Pharmaceutics, 2022 - mdpi.com
The unmet need to develop novel approaches for cancer diagnosis and treatment has led to
the evolution of theranostic agents, which usually include, in addition to the anticancer drug …

Development of bioactive gemcitabine-D-Lys6-GnRH prodrugs with linker-controllable drug release rate and enhanced biopharmaceutical profile

N Sayyad, EI Vrettos, T Karampelas… - European journal of …, 2019 - Elsevier
Peptide-drug conjugates have emerged as a potent approach to enhance the targeting and
pharmacokinetic profiles of drugs. However, the impact of the linker unit has not been …