Among the multitude of chemical modifications that have been described over the past two
decades, oligonucleotide analogs that are modified at the 2′‐position of the furanose sugar …

Numerous chemically modified oligonucleotides have been developed so far and show their
own unique chemical properties and pharmacodynamic/pharmacokinetic characteristics …

The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of
choice to manipulate gene expression in mammalian cell culture, yet improvements of …

We have recently shown that combining the structural elements of 2′ O-methoxyethyl
(MOE) and locked nucleic acid (LNA) nucleosides yielded a series of nucleoside …

Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene
function in mammalian cells yet trigger unintended gene silencing due to their inherent …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

The novel bridged nucleic-acid analogue 2 ', 4 '-BNANC (2 '-O, 4 '-C-aminomethylene
bridged nucleic acid), containing a six-membered bridged structure with an N− O linkage …

Nucleic acid based therapeutics have an allure for medicinal chemists due to their potential
for specific control of gene expression. Persistent efforts have resulted in the FDA approval …

Peptide nucleic acid (PNA) is a synthetic mimic of DNA and RNA that can recognize double-
stranded B-DNA through direct Watson− Crick base-pairing. Although promising, PNA …

Ribofuranose sugar conformation plays an important role in the structure and dynamics of
functional nucleic acids such as siRNAs, AONs, aptamers, miRNAs, etc. To improve their …