Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for transcriptome-wide analysis of differential gene expression and differential splicing of …
Joint profiling of chromatin accessibility and gene expression in individual cells provides an opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …
Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form …
Tissue regeneration requires coordination between resident stem cells and local niche cells,. Here we identify that senescent cells are integral components of the skeletal muscle …
The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
H Weng, F Huang, Z Yu, Z Chen, E Prince, Y Kang… - Cancer Cell, 2022 - cell.com
Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles and show promise as therapeutic targets in human cancers, including acute myeloid …
Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished …