The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management
continues to provide a unique and authoritative comparison of asthma and COPD. Written …

Studies in animal models form the basis for much of our current understanding of the
pathophysiology of asthma, and are central to the preclinical development of drug therapies …

Allergic asthma rates have increased steadily in developed countries, arguing for an
environmental aetiology. To assess the influence of gut microbiota on experimental murine …

Pulmonary function analysis is an important tool in the evaluation of mouse respiratory
disease models, but much controversy still exists on the validity of some tests. Most …

Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …

Mutations in a group of genes that contribute to ciliary function cause Bardet–Biedl
syndrome (BBS). Most studies of BBS have focused on primary, sensory cilia. Here, we …

Asthma is a major cause of morbidity and mortality, affecting some 300 million people
throughout the world. 1 More than 8% of the US population has asthma, with the prevalence …

Celastrol has anti-inflammatory and immunomodulatory activities, but its anti-allergic effects
remain poorly understood. Therefore, we aimed to investigate the ability of celastrol to inhibit …

Pollen-food allergy syndrome (PFAS) is caused by cross-reaction of a specific pollen
antigen with the corresponding food allergen in sensitized individuals. The manifestations …

In a complex inflammatory airways disease such as asthma, abnormalities in a plethora of
molecular and cellular pathways ultimately culminate in characteristic impairments in …