Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)

L Rong, J Zou, W Ran, X Qi, Y Chen, H Cui… - Frontiers in …, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a series of diseases, involving excessive lipid
deposition in the liver and is often accompanied by obesity, diabetes, dyslipidemia …

NAFLD and thyroid function: pathophysiological and therapeutic considerations

E Hatziagelaki, SA Paschou, M Schön… - Trends in Endocrinology …, 2022 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic,
but also extrahepatic, complications. Thyroid hormones are master regulators of energy and …

[HTML][HTML] Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments

L Petagine, MG Zariwala, VB Patel - World Journal of …, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a
leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at …

Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis

EK Wirth, T Puengel, J Spranger… - Expert Review of …, 2022 - Taylor & Francis
Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic
liver disease worldwide and closely interconnected to the metabolic syndrome. Liver …

NAFLD and NASH: etiology, targets and emerging therapies

S Wei, L Wang, PC Evans, S Xu - Drug Discovery Today, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose a
significant threat to human health and cause a tremendous socioeconomic burden …

Current therapeutical approaches targeting lipid metabolism in NAFLD

M Vitulo, E Gnodi, G Rosini, R Meneveri… - International Journal of …, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD, including nonalcoholic fatty liver (NAFL) and
nonalcoholic steatohepatitis (NASH)) is a high-prevalence disorder, affecting about 1 billion …

Thyroid hormone and mitochondrial dysfunction: therapeutic implications for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

R Ramanathan, SA Patwa, AH Ali, JA Ibdah - Cells, 2023 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly termed
nonalcoholic fatty liver disease (NAFLD), is a widespread global health concern that affects …

Understanding the relationship between nonalcoholic fatty liver disease and thyroid disease

P Vidal-Cevallos, S Murúa-Beltrán Gall… - International Journal of …, 2023 - mdpi.com
The prevalence of hypothyroidism in patients with nonalcoholic fatty liver disease (NAFLD)
is high (22.4%). Thyroid hormones (THs) regulate many metabolic activities in the liver by …

Actions of thyroid hormones and thyromimetics on the liver

RA Sinha, E Bruinstroop, PM Yen - Nature Reviews Gastroenterology & …, 2024 - nature.com
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the
liver and entire body. Dysregulation of the hypothalamus–pituitary–thyroid axis can …

Cell-specific transport and thyroid hormone receptor isoform selectivity account for hepatocyte-targeted thyromimetic action of MGL-3196

GS Hönes, RG Sivakumar, C Hoppe, J König… - International journal of …, 2022 - mdpi.com
Thyroid hormones (THs) and TH receptor-beta (TRβ) reduce hepatic triglycerides, indicating
a therapeutic potential for TH analogs in liver steatosis. To avoid adverse extrahepatic …