[HTML][HTML] Chemical composition of circulating native and desialylated low density lipoprotein: what is the difference?

VI Alipov, VN Sukhorukov, VP Karagodin… - Vessel Plus, 2017 - oaepublish.com
Atherosclerosis and related cardiovascular disorders remain the leading global cause of
morbidity and mortality. Modified low density lipoprotein (LDL) is considered to play a crucial …

Neutrophils as a novel target of modified low-density lipoproteins and an accelerator of cardiovascular diseases

T Obama, H Itabe - International journal of molecular sciences, 2020 - mdpi.com
Neutrophil extracellular traps (NETs) significantly contribute to various pathophysiological
conditions, including cardiovascular diseases. NET formation in the vasculature exhibits …

Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo

YC Wang, AS Lee, LS Lu, LY Ke, WY Chen… - Aging cell, 2018 - Wiley Online Library
Dysregulation of plasma lipids is associated with age‐related cardiovascular diseases. L5,
the most electronegative subfraction of chromatographically resolved low‐density …

Lipoprotein sialylation in atherosclerosis: Lessons from mice

L Yu, J Peng, C Mineo - Frontiers in Endocrinology, 2022 - frontiersin.org
Sialylation is a dynamically regulated modification, which commonly occurs at the terminal of
glycan chains in glycoproteins and glycolipids in eukaryotic cells. Sialylation plays a key role …

Increased APOE glycosylation plays a key role in the atherogenicity of L5 low‐density lipoprotein

LY Ke, HC Chan, CC Chen, CF Chang… - The FASEB …, 2020 - Wiley Online Library
Low‐density lipoprotein (LDL) is heterogeneous, composed of particles with variable
atherogenicity. Electronegative L5 LDL exhibits atherogenic properties in vitro and in vivo …

Molecular and cellular mechanisms of electronegative lipoproteins in cardiovascular diseases

LY Ke, SH Law, VK Mishra, F Parveen, HC Chan… - Biomedicines, 2020 - mdpi.com
Dysregulation of glucose and lipid metabolism increases plasma levels of lipoproteins and
triglycerides, resulting in vascular endothelial damage. Remarkably, the oxidation of lipid …

[HTML][HTML] Electronegative LDL induces MMP-9 and TIMP-1 release in monocytes through CD14 activation: Inhibitory effect of glycosaminoglycan sulodexide

D Ligi, S Benitez, L Croce, A Rivas-Urbina… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Objective Electronegative LDL (LDL (−)) is involved in atherosclerosis through the
activation of the TLR4/CD14 inflammatory pathway in monocytes. Matrix metalloproteinases …

[PDF][PDF] Modified low-density lipoproteins as biomarkers in diabetes and metabolic syndrome

A Rivas-Urbina, S Benitez, A Perez… - … . Biosci.(Landmark Ed …, 2018 - researchgate.net
Protein- mediated enamel mineralization Page 1 1220 Modified low-density lipoproteins as
biomarkers in diabetes and metabolic syndrome Andrea Rivas-Urbina1,2, Sonia Benitez1 …

The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications

S Akyol, J Lu, O Akyol, F Akcay, F Armutcu… - Trends in …, 2017 - Elsevier
Cardiovascular disease (CVD) is a health problem of great concern to both the public and
medical authorities. Low-density lipoprotein (LDL) has been reported to play an important …

Range of L5 LDL levels in healthy adults and L5's predictive power in patients with hyperlipidemia or coronary artery disease

CS Chu, HC Chan, MH Tsai, N Stancel, HC Lee… - Scientific Reports, 2018 - nature.com
Electronegative L5 low-density lipoprotein (LDL) level may be a useful biomarker for
predicting cardiovascular disease. We determined the range of plasma L5 levels in healthy …