Therapeutic targeting of regulatory T cells in cancer
F Shan, A Somasundaram, TC Bruno, CJ Workman… - Trends in cancer, 2022 - cell.com
The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
The TNF family of ligands and receptors: communication modules in the immune system and beyond
C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
TNF and ROS crosstalk in inflammation
Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular
homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and …
homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and …
[HTML][HTML] Role of TNF–TNF receptor 2 signal in regulatory T cells and its therapeutic implications
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …
[HTML][HTML] Drugs for autoimmune inflammatory diseases: from small molecule compounds to anti-TNF biologics
Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …
[HTML][HTML] The TNF receptor superfamily in co-stimulating and co-inhibitory responses
Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …
for coordinating multiple cell types into an effective host defense system against pathogens …
[HTML][HTML] TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects
L Probert - Neuroscience, 2015 - Elsevier
Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …
defense and inflammatory responses but under certain circumstances also triggers cell …
[HTML][HTML] Selective targeting of TNF receptors as a novel therapeutic approach
R Fischer, RE Kontermann… - Frontiers in cell and …, 2020 - frontiersin.org
Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …
TNF in the era of immune checkpoint inhibitors: friend or foe?
AY Chen, JD Wolchok, AR Bass - Nature Reviews Rheumatology, 2021 - nature.com
Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …
cancer and have emerged as a pillar of standard cancer care. However, their use is …
[HTML][HTML] Tumor necrosis factor α blockade: an opportunity to tackle breast cancer
MF Mercogliano, S Bruni, PV Elizalde… - Frontiers in …, 2020 - frontiersin.org
Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …
by malignancy in women and represents a main problem for public health worldwide. Tumor …