Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

PT Morse, J Wan, J Bell, I Lee… - Biochemical Society …, 2022 - portlandpress.com
Ischemic stroke affects over 77 million people annually around the globe. Due to the
blockage of a blood vessel caused by a stroke, brain tissue becomes ischemic. While …

[HTML][HTML] Regulation of mitochondrial oxidative phosphorylation through tight control of cytochrome c oxidase in health and disease–implications for ischemia …

L Pham, T Arroum, J Wan, L Pavelich, J Bell, PT Morse… - Redox Biology, 2024 - Elsevier
Mitochondria are essential to cellular function as they generate the majority of cellular ATP,
mediated through oxidative phosphorylation, which couples proton pumping of the electron …

Beneficial effects of theta-burst transcranial magnetic stimulation on stroke injury via improving neuronal microenvironment and mitochondrial integrity

X Zong, Y Dong, Y Li, L Yang, Y Li, B Yang… - Translational stroke …, 2020 - Springer
Recent work suggests that repetitive transcranial magnetic stimulation (rTMS) may
beneficially alter the pathological status of several neurological disorders, although the …

[HTML][HTML] Transcranial photobiomodulation in the management of brain disorders

K Montazeri, M Farhadi, R Fekrazad… - … of Photochemistry and …, 2021 - Elsevier
Transcranial photobiomodulation (tPBM) is the process of delivering light photons through
the skull to benefit from its modifying effect. Brain disorders are important health problems …

Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest

JM Wider, E Gruley, PT Morse, J Wan, I Lee, AR Anzell… - Critical Care, 2023 - Springer
Background Brain injury is a leading cause of morbidity and mortality in patients resuscitated
from cardiac arrest. Mitochondrial dysfunction contributes to brain injury following cardiac …

[HTML][HTML] Quantum biology in low level light therapy: death of a dogma

AP Sommer, P Schemmer, AE Pavláth… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background It is shown that despite exponential increase in the number of clinically exciting
results in low level light therapy (LLLT), scientific progress in the field is retarded by a wrong …

Stress-mediated generation of deleterious ROS in healthy individuals-role of cytochrome c oxidase

R Ramzan, S Vogt, B Kadenbach - Journal of Molecular Medicine, 2020 - Springer
Psychosocial stress is known to cause an increased incidence of coronary heart disease. In
addition, multiple other diseases like cancer and diabetes mellitus have been related to …

Light-emitting diode phototherapy: pain relief and underlying mechanisms

WW Zhang, XY Wang, YX Chu, YQ Wang - Lasers in Medical Science, 2022 - Springer
Pain is a common symptom of an illness. For decades, pain treatments such as non-
steroidal anti-inflammatory drugs, opioids, and surgical nerve blocking have been widely …

Quantification of the severity of hypoxic-ischemic brain injury in a neonatal preclinical model using measurements of cytochrome-c-oxidase from a miniature …

P Kaynezhad, S Mitra, G Bale, C Bauer… - …, 2019 - spiedigitallibrary.org
We describe the development of a miniaturized broadband near-infrared spectroscopy
system (bNIRS), which measures changes in cerebral tissue oxyhemoglobin ([HbO2]) and …

Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for …

HA Kalpage, J Wan, PT Morse, I Lee, M Hüttemann - Cells, 2020 - mdpi.com
We previously reported that serine-47 (S47) phosphorylation of cytochrome c (Cyt c) in the
brain results in lower cytochrome c oxidase (COX) activity and caspase-3 activity in vitro. We …