Mitochondria tailor their morphology to execute their specialized functions in different cell
types and/or different environments. During spermatogenesis, mitochondria undergo …

Sperm carries male genetic information, and flagella help move the sperm to reach oocytes.
When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte …

The axonemal dynein arms (outer (ODA) and inner dynein arms (IDAs)) are multiprotein
structures organized by light, intermediate, light intermediate (LIC), and heavy chain …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

Male infertility is an important health concern that is expected to have a major genetic
etiology. Although high-throughput sequencing has linked gene defects to more than 50% of …

Multiple morphological abnormalities of the sperm flagella (MMAF) are the most severe form
of asthenozoospermia due to impaired axoneme structure in sperm flagella. Dynein arms …

Sleep has been related to a variety of health outcomes. However, no association between
sleep and asthenozoospermia has been reported. The aim of this study is to first investigate …

Background The spermatozoon has a complex molecular apparatus necessary for
fertilization in its head and flagellum. Recently, numerous genes that are needed to …

Background Male infertility is a worldwide population health concern, but its aetiology
remains largely understood. Although CFAP70 variants have already been reported in two …

STUDY QUESTION Are there other pathogenic genes for asthenoteratozoospermia (AT)?
SUMMARY ANSWER DNAH3 is a novel candidate gene for AT in humans and mice. WHAT …