Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …

Mesoscale physical principles of collective cell organization

X Trepat, E Sahai - Nature Physics, 2018 - nature.com
We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

High-frequency microrheology reveals cytoskeleton dynamics in living cells

A Rigato, A Miyagi, S Scheuring, F Rico - Nature physics, 2017 - nature.com
Living cells are viscoelastic materials, dominated by an elastic response on timescales
longer than a millisecond. On shorter timescales, the dynamics of individual cytoskeleton …

Emergent complexity of the cytoskeleton: from single filaments to tissue

F Huber, J Schnauß, S Rönicke, P Rauch… - Advances in …, 2013 - Taylor & Francis
Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Mechanics of biological networks: from the cell cytoskeleton to connective tissue

RH Pritchard, YYS Huang, EM Terentjev - Soft matter, 2014 - pubs.rsc.org
From the cell cytoskeleton to connective tissues, fibrous networks are ubiquitous in
metazoan life as the key promoters of mechanical strength, support and integrity. In recent …

Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness

R Krishnan, CY Park, YC Lin, J Mead, RT Jaspers… - PloS one, 2009 - journals.plos.org
Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate.
Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely …

Cytosolic actin isoforms form networks with different rheological properties that indicate specific biological function

P Nietmann, K Kaub, A Suchenko, S Stenz… - Nature …, 2023 - nature.com
The implications of the existence of different actins expressed in epithelial cells for network
mechanics and dynamics is investigated by microrheology and confocal imaging. γ-actin …

Biomechanics: cell research and applications for the next decade

D Discher, C Dong, JJ Fredberg, F Guilak… - Annals of biomedical …, 2009 - Springer
With the recent revolution in Molecular Biology and the deciphering of the Human Genome,
understanding of the building blocks that comprise living systems has advanced rapidly. We …

Universal glass-forming behavior of in vitro and living cytoplasm

K Nishizawa, K Fujiwara, M Ikenaga, N Nakajo… - Scientific reports, 2017 - nature.com
Physiological processes in cells are performed efficiently without getting jammed although
cytoplasm is highly crowded with various macromolecules. Elucidating the physical …

[HTML][HTML] Physical properties of cytoplasmic intermediate filaments

J Block, V Schroeder, P Pawelzyk… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Intermediate filaments (IFs) constitute a sophisticated filament system in the cytoplasm of
eukaryotes. They form bundles and networks with adapted viscoelastic properties and are …