The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low
toxicity remain challenging, and obtaining such agents continues to be an active area of …

Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

Alkaloids are a diverse group of natural phytochemicals. These phytochemicals in plants
provide them protection against pests, and herbivorous organisms and also control their …

Phosphine‐catalyzed enantioselective annulation reactions involving ketimines are a
daunting synthetic challenge owing to the intrinsic low reactivity of ketimine substrates. A …

Tunneling nanotubes (TNTs), the long membrane extensions connecting distant cells, have
emerged as a novel form of cell-to-cell communication. However, it is not fully understood …

Since recent publications suggested that the survival of cancer cells depends on MTH1 to
avoid incorporation of oxidized nucleotides into the cellular DNA, MTH1 has attracted …

The human immunodeficiency virus type 1 (HIV-1) Vpr protein is an attractive target for
antiretroviral drug development. The conservation both of the structure along virus evolution …

Identification of the cellular targets of bioactive small molecules is a crucial step in drug
discovery and chemical genetics. Classical affinity purification with small-molecule affinity …

The attempts to increase novel drug productivity through creative discovery technologies
have fallen short of producing the satisfactory results. For these reasons, evolved from the …