Neutralization of virus infectivity by antibodies is an important component of immunity to
several virus infections. Here, the immunochemical basis for the action of neutralizing …

▪ Abstract HIV-1 particles are decorated with a network of densely arranged envelope spikes
on their surface. Each spike is formed of a trimer of heterodimers of the gp120 surface and …

Alanine scanning mutagenesis was performed on monomeric gp120 of human
immunodeficiency virus type 1 to systematically identify residues important for gp120 …

IgG1 b12 is a broadly neutralizing antibody against human immunodeficiency virus type 1
(HIV-1). The epitope recognized by b12 overlaps the CD4 receptor-binding site (CD4bs) on …

The ability to induce broadly neutralizing antibodies should be a key component of any
forthcoming vaccine against human immunodeficiency virus type 1. One potential vaccine …

We previously described a human immunodeficiency virus type 1 (HIV-1) envelope mutant
that introduces a disulfide bridge between the gp120 surface proteins and gp41 …

HIV-1 vaccine research has obtained an enormous boost since the discovery of many
broadly neutralizing antibodies (bnAbs) targeting all accessible sites on the HIV-1 envelope …

The anchored and secreted forms of the human immunodeficiency virus type 1 (HIV-1) 89.6
envelope glycoprotein, either complete or after deletion of the V3 loop, were expressed in a …

Successful vaccination programs, particularly against inffuenza virus infection, have
provided us with an awareness of the need to immunize against the predominant circulating …

Viruses that infect eukaryotic organisms have the unique characteristic of self-assembling
into particles. The mammalian immune system is highly attuned to recognizing and attacking …