Endothelial function in pulmonary arterial hypertension: from bench to bedside

M Correale, F Chirivì, EML Bevere, L Tricarico… - Journal of Clinical …, 2024 - mdpi.com
Pulmonary arterial hypertension is a complex pathology whose etiology is still not
completely well clarified. The pathogenesis of pulmonary arterial hypertension involves …

Advances in the research of sulfur dioxide and pulmonary hypertension

X Liu, H Zhou, H Zhang, H Jin, Y He - Frontiers in Pharmacology, 2023 - frontiersin.org
Pulmonary hypertension (PH) is a fatal disease caused by progressive pulmonary vascular
remodeling (PVR). Currently, the mechanisms underlying the occurrence and progression of …

[HTML][HTML] A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis)

Q Ge, T Zhang, J Yu, X Lu, S Xiao, T Zhang… - Biomedicine & …, 2024 - Elsevier
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease characterized by
elevated pulmonary vascular resistance, progressive increases in pulmonary artery …

[HTML][HTML] The Prospect and Challenges of Repurposing Established Drugs in Pulmonary Arterial Hypertension

SO Sener, R Nasim, T Nasim - BioChem, 2024 - mdpi.com
Pulmonary arterial hypertension (PAH) is a progressive disorder caused by the narrowing of
small blood vessels in the lungs, which, in the absence of therapies, leads to right heart …

5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase promotes pulmonary arterial smooth muscle cell …

X Shi, Q Ma, Y Huo, Y Su - American Journal of Physiology …, 2024 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is a debilitating vascular disorder characterized by
abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and collagen …

Derivation and internal validation of prediction models for pulmonary hypertension risk assessment in a cohort inhabiting Tibet, China

J Tang, R Yang, H Li, X Wei, Z Yang, W Cai, Y Jiang… - eLife, 2024 - elifesciences.org
Individuals residing in plateau regions are susceptible to pulmonary hypertension (PH) and
there is an urgent need for a prediction nomogram to assess the risk of PH in this population …

[HTML][HTML] Current Pharmaceutical Strategies in the Management of Persistent Pulmonary Hypertension of the Newborn (PPHN): A Comprehensive Review of …

D Kaplish, JD Vagha, S Rathod, A Jain - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Persistent Pulmonary Hypertension of the Newborn (PPHN) is a life-threatening condition
characterized by the failure of normal circulatory transition after birth, leading to sustained …

Natriuretic peptide system in hypertension: Current understandings of its regulation, targeted therapies and future challenges

V Shelke, N Dagar, B Puri, AB Gaikwad - European Journal of …, 2024 - Elsevier
The natriuretic peptide system (NPS) is the key driving force of the heart's endocrine
function. Recent developments in NPS-targeted therapies have been found promising and …

Integrating pharmacogenetics, multi‐omics and machine learning in the novel therapeutic view of pulmonary hypertension

C Li, J Xue, D Zhou, X Qi, T Chen… - Interdisciplinary …, 2025 - Wiley Online Library
It is a complex disease with multiple pathogenesis that causes pulmonary hypertension
(PH). In addition to the commonly used drugs for treating PH, pharmacogenomic therapies …

Dehydrodiisoeugenol inhibits PDGF-BB-induced proliferation and migration of human pulmonary artery smooth muscle cells via the mTOR/HIF1-α/HK2 signaling …

S Xie, J Zhao, F Zhang, X Li, X Yu, Z Shu… - Toxicology and Applied …, 2025 - Elsevier
Abnormal proliferation and migration of pulmonary artery smooth muscle cells (PASMCs)
leading to pulmonary vascular remodeling are critical factors in the development of …