The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Pleiotropy refers to the phenomenon of one gene or one mutation affecting multiple
phenotypic traits. While the concept of pleiotropy is as old as Mendelian genetics, functional …

Although pairwise interactions have always had a key role in ecology and evolutionary
biology, the recent increase in the amount and availability of biological data has placed a …

Most proteins do not evolve in isolation, but as components of complex genetic networks.
Therefore, a protein's position in a network may indicate how central it is to cellular function …

Abstract Lay Summary: An evolutionary mechanism of aging was hypothesized 60 years
ago to be the genetic trade-off between early life fitness and late life mortality. Genetic …

When people age their mortality rate increases exponentially, following Gompertz's law.
Even so, individuals do not die from old age. Instead, they accumulate age-related illnesses …

Varios elementos epistemológicos y metodológicos han sido propuestos como tendencia
alternativa a la ciencia contemporánea, agrupados bajo el rótulo de" nuevo paradigma" y …

Pleiotropy refers to the observation of a single gene influencing multiple phenotypic traits.
Although pleiotropy is a common phenomenon with broad implications, its molecular basis …

By serving as intermediaries between cellular metabolism and the bioenergetic demands of
proliferation, endolysosomes allow cancer cells to thrive under normally detrimental …