Global waves synchronize the brain's functional systems with fluctuating arousal

RV Raut, AZ Snyder, A Mitra, D Yellin, N Fujii… - Science …, 2021 - science.org
We propose and empirically support a parsimonious account of intrinsic, brain-wide
spatiotemporal organization arising from traveling waves linked to arousal. We hypothesize …

Vigilance effects in resting-state fMRI

TT Liu, M Falahpour - Frontiers in neuroscience, 2020 - frontiersin.org
Measures of resting-state functional magnetic resonance imaging (rsfMRI) activity have
been shown to be sensitive to cognitive function and disease state. However, there is …

[HTML][HTML] Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology

F Han, J Chen, A Belkin-Rosen, Y Gu, L Luo… - PLoS …, 2021 - journals.plos.org
The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau
proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance …

Resting-state global brain activity affects early β-amyloid accumulation in default mode network

F Han, X Liu, RB Mailman, X Huang, X Liu - Nature communications, 2023 - nature.com
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease
(AD), first accumulates cortically in the default mode network (DMN), years before AD …

[HTML][HTML] Imaging the temporal dynamics of brain states with highly sampled fMRI

Z Yang, LD Lewis - Current opinion in behavioral sciences, 2021 - Elsevier
The spontaneous dynamics of the brain modulate its function from moment to moment,
shaping neural computation and cognition. Functional MRI (fMRI), while classically used as …

Brain activity fluctuations propagate as waves traversing the cortical hierarchy

Y Gu, LE Sainburg, S Kuang, F Han… - Cerebral …, 2021 - academic.oup.com
The brain exhibits highly organized patterns of spontaneous activity as measured by resting-
state functional magnetic resonance imaging (fMRI) fluctuations that are being widely used …

Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson's disease cognitive decline

F Han, GL Brown, Y Zhu, AE Belkin‐Rosen… - Movement …, 2021 - Wiley Online Library
Background Deposition and spreading of misfolded proteins (α‐synuclein and tau) have
been linked to Parkinson's disease cognitive dysfunction. The glymphatic system may play …

Single-neuron firing cascades underlie global spontaneous brain events

X Liu, DA Leopold, Y Yang - Proceedings of the National …, 2021 - National Acad Sciences
The resting brain consumes enormous energy and shows highly organized spontaneous
activity. To investigate how this activity is manifest among single neurons, we analyzed …

Development of neonatal brain functional centrality and alterations associated with preterm birth

S Fenn-Moltu, SP Fitzgibbon, J Ciarrusta… - Cerebral …, 2023 - academic.oup.com
Formation of the functional connectome in early life underpins future learning and behavior.
However, our understanding of how the functional organization of brain regions into …

[HTML][HTML] The association between head motion during functional magnetic resonance imaging and executive functioning in older adults

HK Hausman, C Hardcastle, JN Kraft… - Neuroimage …, 2022 - Elsevier
Minimizing head motion during functional magnetic resonance imaging (fMRI) is important
for maintaining the integrity of neuroimaging data. While there are a variety of techniques to …