Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Statins, which are competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A
reductase, reduce cholesterol blood levels and the risk of developing cardiovascular …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

Monacolin K (MK) is the principal active substance in Monascus-fermentation products (eg
red yeast rice). MK is effective in reducing cholesterol levels in humans and has been widely …

Background Many drugs approved for other indications can control the growth of tumor cells
and limit adverse events (AE). Data sources Literature searches with keywords 'repurposing …

The time and cost of developing new drugs have led many groups to limit their search for
therapeutics to compounds that have previously been approved for human use. Many …

Simple Summary Statins are crucial for managing lipid disorders by inhibiting HMG-CoA
reductase, reducing cholesterol levels, and lowering cardiovascular disease risk. Beyond …

Emergence of novel treatment modalities provides effective therapeutic options, apart from
conventional cytotoxic chemotherapy, to fight against colorectal cancer. Unfortunately, drug …

Simple Summary Despite improvements in standardized screening methods and the
development of promising therapies for colorectal cancer (CRC), survival rates are still low …

Cholesterol dyshomeostasis in cancer cells leads to intracellular cholesterol accumulation,
which imparts drug resistance and allows these cells to evade apoptotic signalling …