Radioprotective role of peroxiredoxin 6

MG Sharapov, VI Novoselov, SV Gudkov - Antioxidants, 2019 - mdpi.com
Peroxiredoxin 6 (Prdx6) is a member of an evolutionary ancient family of peroxidase
enzymes with diverse functions in the cell. Prdx6 is an important enzymatic antioxidant. It …

Role of glutathione peroxidases and peroxiredoxins in free radical-induced pathologies

MG Shaparov, SV Gudkov, VZ Lankin… - Biochemistry (Moscow …, 2021 - Springer
In this review, we discuss the pathogenesis of some socially significant diseases associated
with the development of oxidative stress, such as atherosclerosis, diabetes, and radiation …

The role of peroxiredoxin 6 in neutralization of X-ray mediated oxidative stress: effects on gene expression, preservation of radiosensitive tissues and postradiation …

MG Sharapov, VI Novoselov, EE Fesenko… - Free Radical …, 2017 - Taylor & Francis
Peroxiredoxins are redox-sensing multifunctional enzymes, among them peroxiredoxin 6
(Prx6) can neutralize the most broadest range of hydroperoxides and play an important role …

Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction

RG Goncharov, MG Sharapov - Molecular Biology, 2023 - Springer
Ischemia–reperfusion is a cascade of complex and interrelated pathological processes
underlying many human diseases, including such socially significant diseases as stroke …

Direct synthesis of 4-organylsulfenyl-7-chloro quinolines and their toxicological and pharmacological activities in Caenorhabditis elegans

WG Salgueiro, MCDF Xavier, LFB Duarte… - European journal of …, 2014 - Elsevier
We describe herein our results on the synthesis and biological properties in Caenorhabditis
elegans of a range of 4-organylsulfenyl-7-chloroquinolines. This class of compounds have …

Peroxiredoxin 6 is a natural radioprotector

MG Sharapov, SV Gudkov, AE Gordeeva… - Doklady Biochemistry …, 2016 - Springer
After injection of 20 mg/kg peroxiredoxin 6 to male Kv: SHK mice 15 min before X-ray
irradiation in the range of lethal doses (7–10 Gy), the mice remained alive for 30 days …

Peroxiredoxins as multifunctional enzymes

MG Sharapov, VK Ravin, VI Novoselov - Molecular biology, 2014 - Springer
Peroxiredoxins are an evolutionary ancient widespread group of selenium-independent
peroxidases. Peroxiredoxins protect cells from various peroxides, play an important role in …

Use of peroxiredoxin for preconditioning of heterotopic heart transplantation in a rat

NV Grudinin, VK Bogdanov, MG Sharapov… - Russian Journal of …, 2020 - journal.transpl.ru
Abstract Peroxiredoxin 6 (Prdx6) is an antioxidant enzyme in the human body that performs
a number of important functions in the cell. Prdx6 restores a wide range of peroxide …

Применение пероксиредоксина для прекондиционирования трансплантата сердца крысы

НВ Грудинин, ВК Богданов, МГ Шарапов… - Вестник …, 2020 - journal.transpl.ru
Аннотация Пероксиредоксин 6 (Prx6) является антиоксидантным ферментом
человеческого организма, выполняющим в клетке ряд важных функций. Prx6 …

Construction of a fusion enzyme exhibiting superoxide dismutase and peroxidase activity

MG Sharapov, VI Novoselov, VK Ravin - Biochemistry (Moscow), 2016 - Springer
A chimeric gene construct encoding human peroxiredoxin 6 and Mn-superoxide dismutase
from Escherichia coli was developed. Conditions for expression of the fusion protein in E …