Managing hemolyzed samples in clinical laboratories

AM Simundic, G Baird, J Cadamuro… - Critical reviews in …, 2020 - Taylor & Francis
Hemolysis is conventionally defined as membrane disruption of red blood cells and other
blood cells that is accompanied by subsequent release of intracellular components into the …

Errors within the total laboratory testing process, from test selection to medical decision-making–A review of causes, consequences, surveillance and solutions

C Mrazek, G Lippi, MH Keppel, TK Felder… - Biochemia …, 2020 - hrcak.srce.hr
Sažetak Laboratory analyses are crucial for diagnosis, follow-up and treatment decisions.
Since mistakes in every step of the total testing process may potentially affect patient safety …

Evaluation of hemolysis, lipemia, and icterus interference with common clinical immunoassays

A Karin, V Higgins, J Miller, D Brinc… - Clinical Chemistry and …, 2023 - degruyter.com
Objectives Hemolysis, icterus, and lipemia (HIL) are common sources of endogenous
interference in clinical laboratory testing. Defining the threshold of interference for …

The preanalytical phase–from an instrument-centred to a patient-centred laboratory medicine

J Cadamuro, AM Simundic - Clinical Chemistry and Laboratory …, 2023 - degruyter.com
In order to guarantee patient safety, medical laboratories around the world strive to provide
highest quality in the shortest amount of time. A major leap in quality improvement was …

[HTML][HTML] Charting the next road map for CSF biomarkers in Alzheimer's disease and related dementias

WT Hu, A Nayyar, M Kaluzova - Neurotherapeutics, 2023 - Elsevier
Clinical prediction of underlying pathologic substrates in people with Alzheimer's disease
(AD) dementia or related dementia syndromes (ADRD) has limited accuracy. Etiologic …

Preanalytical quality improvement–an interdisciplinary journey

J Cadamuro, G Baird, G Baumann… - Clinical Chemistry and …, 2022 - degruyter.com
Since the beginning of laboratory medicine, the main focus was to provide high quality
analytics. Over time the importance of the extra-analytical phases and their contribution to …

Methods to reduce lipemic interference in clinical chemistry tests: a systematic review and recommendations

SX Soh, TP Loh, SK Sethi, L Ong - Clinical Chemistry and Laboratory …, 2022 - degruyter.com
Objectives Lipemia is the presence of abnormally high lipoprotein concentrations in serum
or plasma samples that can interfere with laboratory testing. There is little guidance …

European survey on preanalytical sample handling–part 1: how do European laboratories monitor the preanalytical phase? On behalf of the European Federation of …

J Cadamuro, G Lippi, A von Meyer, M Ibarz… - Biochemia …, 2019 - hrcak.srce.hr
Sažetak Introduction: Compared to other activities of the testing process, the preanalytical
phase is plagued by a lower degree of standardization, which makes it more vulnerable to …

Behind the curtain: therapeutic drug monitoring of psychotropic drugs from a laboratory analytical perspective

M Scherf-Clavel, P Baumann, XM Hart… - Therapeutic Drug …, 2022 - journals.lww.com
Purpose: Therapeutic drug monitoring (TDM) is a well-established tool for guiding
psychopharmacotherapy and improving patient care. Despite their established roles in the …

Hemolysis interference in 10 coagulation assays on an instrument with viscosity‐based, chromogenic, and turbidimetric clot detection

Y Hedeland, CM Gustafsson, Z Touza… - International Journal of …, 2020 - Wiley Online Library
Introduction Hemolysate in plasma samples from patients may cause misleading results in
coagulation assays. Even though modern coagulation instruments often are equipped with …