Biological roles of glycans

A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Congenital disorders of glycosylation: Still “hot” in 2020

N Ondruskova, A Cechova, H Hansikova… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Congenital disorders of glycosylation (CDG) are inherited metabolic diseases
caused by defects in the genes important for the process of protein and lipid glycosylation …

Perspectives on glycosylation and its congenital disorders

BG Ng, HH Freeze - Trends in Genetics, 2018 - cell.com
Congenital disorders of glycosylation (CDG) are a rapidly expanding group of metabolic
disorders that result from abnormal protein or lipid glycosylation. They are often difficult to …

What is new in CDG?

J Jaeken, R Péanne - Journal of inherited metabolic disease, 2017 - Springer
Congenital disorders of glycosylation (CDG) are one group among the disorders of
glycosylation. The latter comprise defects associated with hypoglycosylation but also defects …

Genetic glycoengineering in mammalian cells

Y Narimatsu, C Büll, YH Chen, HH Wandall… - Journal of Biological …, 2021 - ASBMB
Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Recent advancements in understanding mammalian O-mannosylation

MO Sheikh, SM Halmo, L Wells - Glycobiology, 2017 - academic.oup.com
The post-translational glycosylation of select proteins by O-linked mannose (O-mannose or
O-man) is a conserved modification from yeast to humans and has been shown to be …

Dystroglycanopathy: from elucidation of molecular and pathological mechanisms to development of treatment methods

M Kanagawa - International Journal of Molecular Sciences, 2021 - mdpi.com
Dystroglycanopathy is a collective term referring to muscular dystrophies with abnormal
glycosylation of dystroglycan. At least 18 causative genes of dystroglycanopathy have been …

Genome diversity of Chinese indigenous chicken and the selective signatures in Chinese gamecock chicken

W Luo, C Luo, M Wang, L Guo, X Chen, Z Li… - Scientific reports, 2020 - nature.com
Gamecock chickens are one of the earliest recorded birds in China, and have accumulated
some unique morphological and behavioral signatures such as large body size, muscularity …

CDG therapies: from bench to bedside

S Brasil, C Pascoal, R Francisco… - International journal of …, 2018 - mdpi.com
Congenital disorders of glycosylation (CDG) are a group of genetic disorders that affect
protein and lipid glycosylation and glycosylphosphatidylinositol synthesis. More than 100 …

The role of nonglycolytic glucose metabolism in myocardial recovery upon mechanical unloading and circulatory support in chronic heart failure

R Badolia, DKA Ramadurai, ED Abel, P Ferrin, I Taleb… - Circulation, 2020 - Am Heart Assoc
Background: Significant improvements in myocardial structure and function have been
reported in some patients with advanced heart failure (termed responders [R]) following left …