Background The human hemoglobin molecules are closely related proteins formed by
symmetric pairing of dimer polypeptide chains into a tetrameric functional structure: HbF …

In various organisms, the Hippo signaling pathway has been identified as a master regulator
of organ size determination and tissue homeostasis. The Hippo signaling coordinates …

Bleeding and thrombosis are known as common complications of polycythemia for a long
time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover …

Hypoxia leads to metabolic changes at the cellular, tissue, and organismal levels. The
molecular mechanisms for controlling physiological changes during hypoxia have not yet …

Erythrocytosis moderately enhances the oxygen-carrying capacity of the blood and is
considered a characteristic response of individuals adapting from low-altitude regions to …

Diabetes mellitus is a chronic metabolic disease that affects more than 10.5% of the world's
adult population. Biochemical and hematological parameters, such as albumin (ALB) and …

Conventional treatments exhibit various side effects on chronic stress anemia.
Extramedullary stress erythropoiesis is a compensatory mechanism, which may effectively …

For decades, mathematical models have been used to understand the course and outcome
of malaria infections (ie, infection dynamics) and the evolutionary dynamics of the parasites …

For decades, mathematical models have been used to understand the course and outcome
of malaria infections (ie, infection dynamics) and the evolutionary dynamics of the parasites …

Highlights•Erythrocytes have unique metabolic requirements for development and
function.•Dysfunctional metabolism contributes to common erythrocyte disorders.• …