Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

In spite of a growing body of research and data, human ageing remains a poorly understood
process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR) …

Human cognitive aging differs between and is malleable within individuals. In the absence
of a strong genetic program, it is open to a host of hazards, such as vascular conditions …

Human senescence has been delayed by a decade. This finding, documented in 1994 and
bolstered since, is a fundamental discovery about the biology of human ageing, and one …

A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Human longevity is a complex phenotype with a significant familial component, yet little is
known about its genetic antecedents. Increasing evidence from animal models suggests that …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …