Modulation of NF-κB signalling by microbial pathogens

MM Rahman, G McFadden - Nature Reviews Microbiology, 2011 - nature.com
The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host
response to infection by microbial pathogens, by orchestrating the innate and acquired host …

Identification and utility of innate immune system evasion mechanisms of ASFV

S Correia, S Ventura, RM Parkhouse - Virus research, 2013 - Elsevier
The interferon (IFN) system is an early innate anti-virus host defense mechanism that takes
place shortly after entry of the pathogen and long before the onset of adaptive immunity …

Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1

T Abe, GN Barber - Journal of virology, 2014 - Am Soc Microbiol
ABSTRACT STING (stimulator of interferon genes) is known to control the induction of innate
immune genes in response to the recognition of cytosolic DNA species, including the …

Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2α phosphorylation

T Ikegami, K Narayanan, S Won, W Kamitani… - PLoS …, 2009 - journals.plos.org
Rift Valley fever virus (RVFV)(genus Phlebovirus, family Bunyaviridae) is a negative-
stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes …

Psychedelics and immunomodulation: novel approaches and therapeutic opportunities

A Szabo - Frontiers in immunology, 2015 - frontiersin.org
Classical psychedelics are psychoactive substances, which, besides their
psychopharmacological activity, have also been shown to exert significant modulatory …

Discovery of a novel type of autophagy targeting RNA

Y Fujiwara, A Furuta, H Kikuchi, S Aizawa… - Autophagy, 2013 - Taylor & Francis
Regulated degradation of cellular components by lysosomes is essential to maintain
biological homeostasis. In mammals, three forms of autophagy, macroautophagy …

Deletion of African swine fever virus (ASFV) H240R gene attenuates the virulence of ASFV by enhancing NLRP3-mediated inflammatory responses

L Huang, H Liu, G Ye, X Liu, W Chen, Z Wang… - Journal of …, 2023 - Am Soc Microbiol
African swine fever (ASF) is a highly contagious infectious disease of domestic pigs and wild
boars caused by African swine fever virus (ASFV), with a mortality rate of up to 100%. In …

Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus

Y Sun, M Han, C Kim, JG Calvert, D Yoo - Viruses, 2012 - mdpi.com
Innate immunity is the first line of defense against viral infection, and in turn, viruses have
evolved to evade host immune surveillance. As a result, viruses may persist in host and …

Hantavirus‐induced immunity in rodent reservoirs and humans

G Schönrich, A Rang, N Lütteke… - Immunological …, 2008 - Wiley Online Library
Hantaviruses are predominantly rodent‐borne pathogens, although recently novel shrew‐
associated hantaviruses were found. Within natural reservoir hosts, hantairuses do not …

The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?

M Mahooti, SM Miri, E Abdolalipour, A Ghaemi - Microbial pathogenesis, 2020 - Elsevier
Respiratory virus infections are among the most prevalent diseases in humans and
contribute to morbidity and mortality in all age groups. Moreover, since they can evolve fast …