It has become increasingly clear that deregulation of the NF κ B signaling cascade is a
common underlying feature of many human ailments including cancers. The past two …

The IκB kinase (IKK) complex is involved in transcriptional activation by phosphorylating the
inhibitory molecule IκBα, a modification that triggers its subsequent degradation, enabling …

In response to stress, cells start transcriptional and transcription‐independent programs that
can lead to adaptation or death. Here, we show that multiple inducers of autophagy …

Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains
poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent …

The inflammasomes are multiprotein complexes that activate caspase-1 in response to
infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report …

More than 100 human genetic skin diseases, impacting over 20% of the population, are
characterized by disrupted epidermal differentiation. A significant proportion of the 90 genes …

Fanconi anemia (FA) is a rare genetic disorder characterized by an increased susceptibility
to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate …

Here, we report that kinase-dead IKKα knockin mice develop spontaneous lung squamous
cell carcinomas (SCCs) associated with IKKα downregulation and marked pulmonary …

It has long been known that excessive mitotic activity due to H-Ras can block keratinocyte
differentiation and cause skin cancer. It is not clear whether there are any innate surveillants …

Psoriasis is a common, chronic and relapsing autoimmune skin disease. Clinical
characteristics of this disease are sharply-demarcated erythematous plaques covered with …