The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

We possess an acute sense of temperature. Most of us seek shade on a hot summer day,
prefer a warm shower to a cold one, and enjoy red wines served at a temperature of 15–18° …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …

TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent
somatosensory neurons that contain substance P and calcitonin gene-related peptide …

A large body of evidence now exists to substantiate that the endocannabinoid, anandamide,
activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a …

Preclinical research has recently uncovered new molecular mechanisms underlying the
generation and transduction of pain, many of which represent opportunities for …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …