Diverse macrophage populations mediate acute lung inflammation and resolution

NR Aggarwal, LS King… - American Journal of …, 2014 - journals.physiology.org
Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct
pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part …

Sepsis biomarkers: a review

C Pierrakos, JL Vincent - Critical care, 2010 - Springer
Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction

X Yan, A Anzai, Y Katsumata, T Matsuhashi… - Journal of molecular and …, 2013 - Elsevier
Acute myocardial infarction (MI) causes sterile inflammation, which is characterized by
recruitment and activation of innate and adaptive immune system cells. Here we delineate …

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding

KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

The pathogenesis of sepsis

DJ Stearns-Kurosawa, MF Osuchowski… - Annual review of …, 2011 - annualreviews.org
Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

S Yousefi, JA Gold, N Andina, JJ Lee, AM Kelly… - Nature medicine, 2008 - nature.com
Although eosinophils are considered useful in defense mechanisms against parasites, their
exact function in innate immunity remains unclear. The aim of this study is to better …

[HTML][HTML] Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding …

R Bartenschlager, TF Baumert, J Bukh, M Houghton… - Virus research, 2018 - Elsevier
The development and clinical implementation of direct-acting antivirals (DAAs) has
revolutionized the treatment of chronic hepatitis C. Infection with any hepatitis C virus (HCV) …

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis

JS Boomer, J Shuherk-Shaffer, RS Hotchkiss… - Critical care, 2012 - Springer
Introduction Severe sepsis is characterized by an initial hyper-inflammatory response that
may progress to an immune-suppressed state associated with increased susceptibility to …

Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients

Y Zhang, J Li, J Lou, Y Zhou, L Bo, J Zhu, K Zhu, X Wan… - Critical care, 2011 - Springer
Introduction Studies on the role of programmed death-1 (PD-1) and its main ligand (PD-L1)
during experimental models of sepsis have shown that the PD-1/PD-L1 pathway plays a …

Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells

J Russier, E Treossi, A Scarsi, F Perrozzi, H Dumortier… - Nanoscale, 2013 - pubs.rsc.org
Graphene oxide (GO) is attracting an ever-growing interest in different fields and
applications. Not much is known about the possible impact of GO sheet lateral dimensions …