Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
MD Brand - Free Radical Biology and Medicine, 2016 - Elsevier
This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …
mitochondria, and the status of different sites of production in redox signaling and pathology …
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …
[HTML][HTML] Oxidative stress in the eye and its role in the pathophysiology of ocular diseases
EW Böhm, F Buonfiglio, AM Voigt, P Bachmann, T Safi… - Redox Biology, 2023 - Elsevier
Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
Macrophages are activated during microbial infection to coordinate inflammatory responses
and host defense. Here we find that in macrophages activated by bacterial …
and host defense. Here we find that in macrophages activated by bacterial …
The sites and topology of mitochondrial superoxide production
MD Brand - Experimental gerontology, 2010 - Elsevier
Mitochondrial superoxide production is an important source of reactive oxygen species in
cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites …
cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites …
Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise
RLS Goncalves, CL Quinlan… - Journal of Biological …, 2015 - ASBMB
The sites and rates of mitochondrial production of superoxide and H 2 O 2 in vivo are not yet
defined. At least 10 different mitochondrial sites can generate these species. Each site has a …
defined. At least 10 different mitochondrial sites can generate these species. Each site has a …
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
N Li, K Ragheb, G Lawler, J Sturgis, B Rajwa… - Journal of Biological …, 2003 - ASBMB
Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce
cell death in a variety of cells. However, the mechanism is still elusive. Because reactive …
cell death in a variety of cells. However, the mechanism is still elusive. Because reactive …
[HTML][HTML] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis
resistance and be therapeutically targeted. Compared to normal cells, several human …
resistance and be therapeutically targeted. Compared to normal cells, several human …
Energy metabolism in tumor cells
R Moreno‐Sánchez, S Rodríguez‐Enríquez… - The FEBS …, 2007 - Wiley Online Library
In early studies on energy metabolism of tumor cells, it was proposed that the enhanced
glycolysis was induced by a decreased oxidative phosphorylation. Since then it has been …
glycolysis was induced by a decreased oxidative phosphorylation. Since then it has been …