Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and
a largely untreatable cause of intracerebral haemorrhage and contributor to age-related …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

Co-pathologies play an important role in the expression of the Alzheimer's disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …

Abstract Purpose of Review The aim of this review is to summarize current conceptual
models of cognitive reserve (CR) and related concepts and to discuss evidence for these …

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the
pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However …

Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …