Bispecific antibodies (bsAbs) have recently emerged as a promising platform for the
treatment of several conditions, most importantly cancer. Based on the combination of two …

Two novel bicyclo [6.1. 0] nonyne (BCN) linker derivatives, which can be directly
incorporated into oligonucleotide sequences during standard automated solid-phase …

Bicyclo [6.1. 0] nonyne carboxylic acid (BCN-COOH) is a valuable intermediate for the
development of bioorthogonal click reagents. A convenient three-step synthesis of pure …

The development of chemical methods for the site-selective modification of proteins have
been widely investigated for the past decades, especially in the therapeutic field. Because of …

Over the past decades, protein modification via chemo-and site-selective strategies has
emerged a new era on therapeutic applications giving breeding ground of intensive studies …

The protein precursor of Hedgehog (Hh) undergoes a distinctive autoprocessing reaction
known as cholesterolysis in which an internal Gly-Cys peptide bond of Hh is cleaved using …