NMR-based approaches in the study of foods

AP Sobolev, C Ingallina, M Spano, G Di Matteo… - Molecules, 2022 - mdpi.com
In this review, the three different NMR-based approaches usually used to study foodstuffs
are described, reporting specific examples. The first approach starts with the food of interest …

The Role of Hidden Conformers in Determination of Conformational Preferences of Mefenamic Acid by NOESY Spectroscopy

KV Belov, LAE Batista de Carvalho, AA Dyshin… - Pharmaceutics, 2022 - mdpi.com
Mefenamic acid has been used as a non-steroidal anti-inflammatory drug for a long time.
However, its practical use is quite limited due to a number of side effects on the intestinal …

Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

I Khodov, V Sobornova, V Mulloyarova, K Belov… - International Journal of …, 2023 - mdpi.com
This study examines the influence of mefenamic acid on the physical and chemical
properties of silica aerogels, as well as its effect on the sorption characteristics of the …

Conformational State of Fenamates at the Membrane Interface: A MAS NOESY Study

IA Khodov, KV Belov, D Huster, HA Scheidt - Membranes, 2023 - mdpi.com
The present work analyzes the 1H NOESY MAS NMR spectra of three fenamates
(mefenamic, tolfenamic, and flufenamic acids) localized in the lipid–water interface of …

An NMR study on hydration and molecular interaction of phytantriol-based liquid crystals

Y Lu, D Zhu, Q Le, Y Wang, W Wang - Pharmaceutics, 2022 - mdpi.com
Phytantriol-based lyotropic liquid crystals (LLCs) have emerged as a new nanodrug delivery
system. However, the understanding of phytantriol-based LLCs is lacking. In this study, we …

Thixotropic Hydrogels Based on Laponite® and Cucurbituril for Delivery of Lipophilic Drug Molecules

M Massaro, G Cinà, A Borrego‐Sánchez… - …, 2024 - Wiley Online Library
Nowadays the use of hydrogels for biomedical purposes is increasing because of their
interesting features that allow the development of targeted drug delivery systems. Herein …

On the mechanism of membrane permeabilization by tamoxifen and 4-hydroxytamoxifen

J Ortiz, JA Teruel, FJ Aranda, A Ortiz - Membranes, 2023 - mdpi.com
Tamoxifen (TMX), commonly used in complementary therapy for breast cancer, also displays
known effects on the structure and function of biological membranes. This work presents an …

Sesquiterpene Lactones with Anti-Inflammatory Activity from the Halophyte Sonchus brachyotus DC

YK Lee, H Lee, YN Kim, J Kang, EJ Jeong, JR Rho - Molecules, 2023 - mdpi.com
There were five sesquiterpene lactones, belonging to the eudesmanolide class, isolated
from the halophyte Sonchus brachyotus DC. The structures of the compounds were …

Binding of Different Cyclosporin Variants to Micelles Evidenced by NMR and MD Simulations

PP Kobchikova, SV Efimov, VV Klochkov - Membranes, 2023 - mdpi.com
Peptides play a critical role in the life of organisms, performing completely different functions.
The biological activity of some peptides, such as cyclosporins, can be determined by the …

The molecular pharmacology and modulation of the proton-activated chloride channel PAC

CL Pearson - 2023 - ora.ox.ac.uk
Proton activated chloride (PAC) channels are activated in response to extracellular acidity,
and mediate outwardly rectifying chloride currents. The channels are encoded by the …