Water exchange rates measure active transport and homeostasis in neural tissue
NH Williamson, R Ravin, TX Cai, M Falgairolle… - PNAS …, 2023 - academic.oup.com
For its size, the brain is the most metabolically active organ in the body. Most of its energy
demand is used to maintain stable homeostatic physiological conditions. Altered …
demand is used to maintain stable homeostatic physiological conditions. Altered …
[HTML][HTML] Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces
Nuclear magnetic resonance (NMR) measurements of water diffusion have been extensively
used to probe microstructure in porous materials, such as biological tissue, however …
used to probe microstructure in porous materials, such as biological tissue, however …
Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence
Water diffusion-weighted MRI is a very powerful tool for probing tissue microstructure, but
disentangling the contribution of compartment-specific structural disorder from cellular …
disentangling the contribution of compartment-specific structural disorder from cellular …
Cumulant Expansion with Localization: A new representation of the diffusion MRI signal
Diffusion MR is sensitive to the microstructural features of a sample. Fine-scale
characteristics can be probed by employing strong diffusion gradients while the low b-value …
characteristics can be probed by employing strong diffusion gradients while the low b-value …
The Diffusion Exchange Ratio (DEXR): A minimal sampling of diffusion exchange spectroscopy to probe exchange, restriction, and time-dependence
Water exchange is increasingly recognized as an important biological process that can
affect the study of biological tissue using diffusion MR. Methods to measure exchange …
affect the study of biological tissue using diffusion MR. Methods to measure exchange …
[PDF][PDF] Multiexponential analysis of diffusion exchange times reveals a distinct exchange process associated with metabolic activity
TX Cai, NH Williamson, R Ravin… - Proceedings of the Annual …, 2023 - nichd.nih.gov
Contrary to prevailing views, recent work suggests that steady-state water exchange
between the intra-and extracellular space is driven, in part, by active metabolic processes …
between the intra-and extracellular space is driven, in part, by active metabolic processes …
[HTML][HTML] On the sampling strategies and models for measuring diffusion exchange with a double diffusion encoding sequence
Water exchange between the different compartments of a heterogeneous specimen can be
characterized via diffusion magnetic resonance imaging (dMRI). Many analysis frameworks …
characterized via diffusion magnetic resonance imaging (dMRI). Many analysis frameworks …
Water exchange and microscopic kurtosis--two sides of the same coin?
Diffusion MRI is sensitive to a wide range of features of the microstructure including
diffusivity, exchange and three sources of diffusional kurtosis: isotropic, anisotropic, and …
diffusivity, exchange and three sources of diffusional kurtosis: isotropic, anisotropic, and …
The interplay between exchange and microscopic kurtosis as measured by diffusion MRI with double diffusion encoding: Theory and simulations
Double diffusion encoding (DDE) makes diffusion MRI sensitive to a wide range of
microstructural features, and the acquired data can be analysed using different approaches …
microstructural features, and the acquired data can be analysed using different approaches …
Diffusion power spectra as a window into dynamic materials architecture
Understanding molecular dynamics in heterogeneous environments is a foundational step
in tuning macromolecular reactivity. This is especially important in the chemical recycling of …
in tuning macromolecular reactivity. This is especially important in the chemical recycling of …