Information decomposition and the informational architecture of the brain

AI Luppi, FE Rosas, PAM Mediano, DK Menon… - Trends in Cognitive …, 2024 - cell.com
To explain how the brain orchestrates information-processing for cognition, we must
understand information itself. Importantly, information is not a monolithic entity. Information …

Gradients of brain organization: Smooth sailing from methods development to user community

J Royer, C Paquola, SL Valk, M Kirschner, SJ Hong… - Neuroinformatics, 2024 - Springer
Multimodal neuroimaging grants a powerful in vivo window into the structure and function of
the human brain. Recent methodological and conceptual advances have enabled …

Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain

AI Luppi, L Uhrig, J Tasserie, CM Signorelli… - Nature …, 2024 - nature.com
A central challenge of neuroscience is to elucidate how brain function supports
consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI …

Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms

AF Khan, Y Iturria-Medina - Translational Psychiatry, 2024 - nature.com
From Alzheimer's disease to amyotrophic lateral sclerosis, the molecular cascades
underlying neurodegenerative disorders remain poorly understood. The clinical view of …

Molecular and micro-architectural mapping of gray matter alterations in psychosis

N García-San-Martín, RAI Bethlehem, A Mihalik… - Molecular …, 2024 - nature.com
The psychosis spectrum encompasses a heterogeneous range of clinical conditions
associated with abnormal brain development. Detecting patterns of atypical …

What anaesthesia reveals about human brains and consciousness

AI Luppi - Nature Human Behaviour, 2024 - nature.com
The combination of general anaesthesia and neuroimaging holds unique potential for
catalysing integrative and translational discovery about human brains and consciousness …

Brain connectivity changes to fast versus slow dopamine increases

P Manza, D Tomasi, L Vines, D Sotelo… - …, 2024 - nature.com
The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on
how fast they raise dopamine in the brain. Yet how the rate of drug-induced dopamine …

Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness

I Mindlin, R Herzog, L Belloli, D Manasova… - Communications …, 2024 - nature.com
Disorders of consciousness (DoC) represent a challenging and complex group of
neurological conditions characterised by profound disturbances in consciousness. The …

Electroencephalography connectome changes in chronic insomnia disorder are correlated with neurochemical signatures

L Yu, W Peng, W Lin, Y Luo, D Hu, G Zhao, H Xu… - Sleep, 2024 - academic.oup.com
Abstract Study Objectives This study aimed to investigate the alterations in resting-state
electroencephalography (EEG) global brain connectivity (GBC) in patients with chronic …

How Do Neurotransmitter Pathways Contribute to Neuroimaging Phenotypes?

A Ebneabbasi, M Afshani, A Seyed-Ahmadi, V Warrier… - medRxiv, 2024 - medrxiv.org
Neuroimaging could accurately reflect human behaviour in health and disease, but the
mechanism by which image-derived phenotypes correspond to neurotransmitter systems …